Heart Issues

Innocent, flow murmurs. These murmurs are caused by normal turbulent blood flowing across heart valves of young dogs. These low-grade murmurs (less than a grade 2) decrease with age as the heart matures and are not associated with congenital heart disease.

Murmurs associated with congenital heart disease. CKCS are susceptible to congenital abnormalities of heart valves on both the right and left side of the heart. Careful physical examination and additional testing facilitates the diagnosis in a young, asymptomatic dog. Over time, progressive deterioration of the congenitally abnormal valve produces symptoms. Narrowing of the pulmonary valve (stenosis) is the most common valve affected on the right side of the heart. On the left side of the heart, both the mitral valve (leaking or regurgitation) and aortic valve (narrow or stenosis) may be affected.

Pulmonary Stenosis. Stenosis of the pulmonary valve produces a systolic murmur heard on the right side of the sternum. The intensity of the murmur is proportional to the severity of the narrowing of the valve and enlargement of the right ventricle. In mild cases, one may only hear a grade 1 or 2 murmur. In more pronounced stages, the dog may develop right-sided heart failure with peripheral edema. In its most severe form, the pulmonary valve is severely deformed and narrowed and the right ventricle enlarged and weak. The right ventricle then fails and cannot pump blood to the lungs, a fatal condition.

Mitral Value Disease. Malformation of the mitral valve leads to blood leaking backward from the left ventricle into left atrium during the pumping action of the left ventricle. This systolic murmur is best heard on the left side of the sternum. Progressive leaking leads to enlargement of the left atrium and ventricle. As blood floods the lungs, the animal develops exertional shortness of breath, and has decreased exercise tolerance. Eventually heart failure results.

Aortic Stenosis. Narrowing of the aortic valve produces a systolic murmur best heard on the left side of the sternum. Similar to pulmonary stenosis, the intensity of the murmur correlates with the degree of severity of the narrowing of the valve. With progressive narrowing, the left ventricle enlarges and thickens in an effort to generate sufficient pressure to propel the blood forward into the aorta. Eventually the left ventricle fails and is unable to eject blood to the body. The murmur is then is barely audible.

Patent Ductus Arterious. Before birth, blood bypasses the deflated lungs through the ductus arteriosus, a hollow blood vessel connecting the pulmonary artery and the aorta. At birth, the lungs inflate and the ductus arteriosus closes, thereby separating the pulmonary and systemic blood flow circuits. In rare situations, the ductus arteriosus fails to close (a patent ductus arterious) and blood flows from the aorta to the pulmonary artery when the left ventricle contracts (systole) and from the pulmonary artery to the aorta when the left ventricle relaxes (diastole). The murmur is continuous, heard in both systole and diastole, on both sides of the sternum. The loudest component is the systolic murmur. A patent ductus arteriosus results in excessive pressure and volume of blood in the lungs. Eventually, both sides of the heart fail.

The panelists concluded that, ideally, Cavaliers should be 5 years of age or older and heart-clear when they are first bred. However, recognizing the problems associated with breeding females for the first time at 5 years of age, the following was recommended as a secondary approach to reducing the incidence of MVD:

The Brood Bitch should be a minimum of two and a half years old with a clear heart and with both parents with clear heart certificates issued at five years of age or older.

The Stud Dog should be a minimum of two and a half years old with a clear heart and with both parents with clear heart certificates issued at five years of age or older.

All clear heart certificates must be signed by Board Certified Veterinary Cardiologists.

To use an older stud dog with a clear heart certificate issued as late in life as possible is highly desirable. However, an older dog with a slight murmur should not be ignored. It is strongly advised that breeding stock under 5 years old be limited to those with clear heart certificates.

The extent of MVD can be decreased, and the age of onset can be delayed, by breeding only Cavaliers which have been examined by Board Certified Veterinary Cardiologists at age 2 1/2 years or older and found free of MVD murmurs, AND whose parents were similarly examined at age 5 years or older and found to be murmur-free. We refer to these dogs as being “Heart-Clear”.

Raising the age of onset of MVD should be every breeder's immediate aim. The best way to approach this is to select breeding stock with good heart records behind them. It is strongly recommended that ALL Cavaliers be auscultated (examined with a stethoscope) by a Board Certified Veterinary Cardiologist at 2 1/2 years of age or older and annually thereafter, especially within a year of being bred, and the results submitted to the Health Registry.

These guidelines are based on the current recommendations of geneticists and cardiologists and may be updated and reissued by the Cavalier King Charles Spaniel Club, USA when further research becomes available.

List of Cardiologists: http://www.acvim.org/Specialist/Search.aspx

Links:
Orthopedic Foundation for Animals (OFA): http://www.offa.org
Canine Health Information Center (CHIC): http://www.caninehealthinfo.org/

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